can you crush valacyclovir clonidine

May 15, 2023 0 Comments

Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Clonidine extended-release tablets may treat ADHD by affecting the part of the brain that controls attention and impulsivity. If you are taking valacyclovir for the treatment of chickenpox, it is best to start taking valacyclovir as soon as possible after the first sign of the chickenpox rash appears, usually within one day. Gastrointestinal effects may also arise due to long-term use of clonidine. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Should I avoid certain foods while taking Valtrex? Kidney diseaseThe effects may be increased because of slower removal of this medicine from the body. However, you should not flush this medication down the toilet. Teimoory M, Arefi M, Behnoush B, Bastani B. If you miss a dose of clonidine extended-release tablets, skip the missed dose and take the next dose as scheduled. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you are having a herpes break out is it good to use both acyclovir ointment and Valtrex (valacyclovir) pill? For non-prescription products, read the label or package ingredients carefully. Does clonidine HCl oral interact with other drugs you are taking? If you miss a dose, take it as soon as you remember. WebSerious Interactions. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. 0000017860 00000 n This branded product is no longer on the market. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Take the missed dose as soon as you remember it. In these cases, your doctor may want to change the dose, or other precautions may be necessary. While valacyclovir is most effective the earlier you use it, its still highly effective for treating oral herpes after the cold sores have fully developed. Many patients who have high blood pressure will not notice any signs of the problem. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. It is important to remember that this medicine will not keep you from spreading herpes to others. Is it ok if I take a lot more Valtrex (valacyclovir) pills now so they'll work faster; or will I overdose? Its an oral antiviral medication that helps lessen the risk of hospitalization or death from COVID-19, and its become more widely available in the U.S. over time. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. If you miss a dose of this medicine, take it as soon as possible. Anti-Inflammatory Diets May Improve Fertility, Exercise May Be an Anti-COVID Secret Weapon, Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox, FAMCICLO; VAL; ACYCLOVIR/VARICELLA; ZOSTER LIVE VACCINE, ACYCLOVIR;VALACYCLOVIR;FAMCICLOVIR/TALIMOGENE LAHERPAREPVEC, SELECTED NEPHROTOXIC AGENTS/IMMUNE GLOBULIN IV (IGIV), Slideshow: What to Know About Fluoroquinolone Antibiotics. Take your next dose at the regular time. WebValacyclovir and Acyclovir may have different side effects The potential side effects from these medications are mostly the same, but there may be slight differences between the two. Medicines that interact with clonidine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with clonidine. Does Valtrex interact with other medications? Web- Do not crush sustained-release product - Immediate-release tablet may disperse in water (20 mL) within 5 minutes cyclophosphamide Cytoxan Tablet Note: drug may be crushed There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Catapres, Kapvay, Catapres-TTS, Duraclon, Nexiclon XR. Clonidine Withdrawal - What Are The Symptoms & How Long Do They Last. Instead, the best way to dispose of your medication is through a medicine take-back program. They will last until treatment starts or they resolve on their own. Contact lens wearers may need to use wetting eye drops since this medication can cause dry eyes. Adults0.1 milligram (mg) two times a day, taken in the morning and at bedtime. Available for Android and iOS devices. Do not take more or less of it or take it more often than prescribed by your doctor. You can use the study as a second opinion to make health care decisions. The extended-release tablet is usually taken once or twice a day with or without food. 0000005279 00000 n Your doctor may adjust your dose as needed. If your dose is different, do not change it unless your doctor tells you to do so. Alcohol can make the side effects from clonidine worse. Drug interactions are reported among people who take Valtrex and Clonidine. Swallow the extended-release tablets whole; do not split, chew or crush them. A suspension can be made by Pharmacy in some centres. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Clonidine should not be stopped suddenly but withdrawn slowly over a few days. Generic alternatives may be available. Talk to your doctor if you are using marijuana (cannabis). This medicine usually comes with patient information leaflet. Valacyclovir Side Effects. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. You may have to take high blood pressure medicine for the rest of your life. Portions of this document last updated: Feb. 01, 2023. Available as something for placing on your gum? If the pills are too large to swallow, it should be OK to. The 17 efficacy and safety of 0000013388 00000 n Created for people with ongoing healthcare needs but benefits everyone. This is true until the sores are completely healed and the scabs have fallen off. Tell your doctor or pharmacist right away if you are unable to take the medication (for example, due to Your doctor may adjust your dose as needed. W\l]'(9bwJWvJ+.@g9;m@[ugoX)m'Gpn^(n9pKz26Z|.{F^+n7AyLmJ U@ ;yI ]:v ImI`}t l/T>#Fmiii PKhG"BA YQI84,-NIBPI)- ` QJJJP@D\@Jl052--@ $6PPHI f&([HIlVAc6e4i@i@\C!ne:hQ:cpc0l eddVKk" ec ``Pf)cmpEY Place the medicine directly into the mouth. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. A skin rash associated with clonidine use has been reported. Keep out of the reach of children. To help clear up your infection, keep taking valacyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. privacy practices. Children below 12 years of ageUse and dose must be determined by your doctor. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Clonidine can slow your heart rate. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Your doctor may adjust your dose as needed. Store at room temperature away from light and moisture. Does clonidine HCl oral interact with other medications? other information we have about you. To use the sharing features on this page, please enable JavaScript. You'll want to take it with some sort of drink that can quickly wash away the taste, like orange juice or a cola drink. eHealthMe is studying from 58,707 Clonidine users for its effectiveness, alternative drugs and more. Swallow the extended-release tablet whole. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Crushed valacyclovir tablets have a very unpleasant taste, but can be administered to children through nasogastric tubes. View complete list of side effects. There are no specific withdrawal symptoms with valacyclovir. Use this medication regularly to get the most benefit from it. Ask your pharmacist about using those products safely. Follow your doctor's orders or the directions on the label. This medication is used alone or with other medications to treat high blood pressure (hypertension). Make sure you tell your doctor if you have any other medical problems, especially: Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes (e.g., pain, burning, or blisters) begin to appear. We study millions of patients and 5,000 more each day. Take clonidine exactly as directed. Selected from data included with permission and copyrighted by First Databank, Inc. trailer URL of this page: https://medlineplus.gov/druginfo/meds/a682243.html. Clonidine belongs to a class of drugs (central alpha agonists) that act in the brain to lower blood pressure. The usual dose is 0.2 mg to 0.6 mg per day, divided and given two times a day. US residents can call their local poison control center at 1-800-222-1222. When used for a long time, this medication may not work as well and may require different dosing or an additional medication. 0000007624 00000 n The tablet is usually taken two times a day at evenly spaced intervals. He told me he didn't know but if I can't crushed throw it in some water, I won't even notice it go crushed. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Check your blood pressure and pulse (heart rate) regularly while taking this medication. Do not stop taking this medication without consulting your doctor. Symptoms of overdose may include: severe dizziness/drowsiness, fainting, slow/irregular heartbeat, slow/shallow breathing, seizures. Ask your healthcare professional how you should dispose of any medicine you do not use. Using Valacyclovir After a Cold Sore Develops. 0000005989 00000 n But you can crush them and dissolve them in a drink. Before taking clonidine IR oral tablets, talk with your doctor about your health history. Clonidine may not be right for you if you have certain medical conditions or other factors affecting your health. These include: Allergic reaction. Therefore, you must continue to use it as directed if you expect to lower your blood pressure and keep it down. Review/update the ChildrenUse and dose must be determined by your doctor. 0000002129 00000 n Call your doctor for medical advice about side effects. Information is also available online at https://www.poisonhelp.org/help. All rights reserved. These side effects may increase the risk of falling. Do not crush or chew slow-release forms of clonidine; swallow whole. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, heart rhythm problems (such as slow/irregular heartbeat, second- or third-degree atrioventricular block). Clonidine is also used and as an aid in smoking cessation therapy and to diagnose pheochromocytoma (a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heart rate). 0000019449 00000 n Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Some reports may have incomplete information. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clonidine. I started taking 2 Valtrex (valacyclovir) tablets 1000mg for my cold sores last night. Reg BMs. These medications may cause some risk when taken together. However, elderly patients are more likely to have age-related kidney disease, which may require an adjustment in the dose of patients receiving valacyclovir. If you are a Mayo Clinic patient, this could For these, please consult a doctor (virtually or in person). How long after takong Valtrex (valacyclovir) for shingles will they go away? If any of these effects last or get worse, tell your doctor or pharmacist promptly. The presence of other medical problems may affect the use of this medicine. It is often used in genital herpes. https://www.mayoclinic.org/drugs-supplements/valacyclovir-oral-route/precautions/drg-20066635, Advertising and sponsorship opportunities, Advanced human immunodeficiency virus (HIV) infection or. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of valacyclovir in the elderly. Less common side effects (affecting less than one percent of users) include the following: Vertigo. Common interactions include osteonecrosis of jaw among females and pain among males. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Clonidine is also used in the treatment of dysmenorrhea (severely painful cramps during menstrual period), hypertensive crisis (a condition in which your blood pressure is very high), Tourette's syndrome (a condition characterized by the need to perform repeated motions or to repeat sounds or words),menopausal hot flashes, and alcohol and opiate (narcotic) withdrawal. To learn more, please visit our, It should work just fine, but probably will taste bad. Licensed for administration via enteral tube, Advice on administration via enteral tube. For recurrent outbreaks of genital herpes, valacyclovir works best if it is used within 24 hours after the symptoms begin to appear. May be administered up until 4 hours before surgery and then reinstated soon after. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Formulations of clonidine are not interchangeable; speak to your pharmacist. Your doctor will tell you which of these are most important for you. Do not double the dose to catch up. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. If it is near the time of the next dose, skip the missed dose. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Your doctor will probably decrease your dose gradually over 2 to days for the regular tablet and 3 to 7 days for the extended-release tablet. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. Common side effects of Acyclovir may include: Diarrhea, nausea, and vomiting. Valacyclovir has several potential side effects, the most common of which (affecting more than one percent of users) are vomiting, diarrhea, headache and nausea. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Duplication for commercial use must be authorized by ASHP. Do not store in the bathroom. Patients in the study may take other drugs besides Valtrex and Clonidine. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. you should know that clonidine extended-release tablets should be used as part of a total treatment program for ADHD, which may include counseling and special education. It is important that you do not run out of clonidine or miss any doses. %PDF-1.5 % Keep this medication in the container it came in, tightly closed, and out of reach of children. WebCan you crush Valtrex? Do not double doses. Clonidine is rapidly absorbed and the peak effects are seen within one to three hours. Regular monitoring of blood pressure and kidney function may be needed. I've had shingles for 3 weeks. What special precautions should I follow? However, spermicidal (sperm-killing) jelly or a diaphragm will probably not help. Children younger than 6 years of ageUse and dose must be determined by your doctor. Personalize this study to your gender and age, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", Lymph follicular hypertrophy (an increase in the size of the lymph node follicles). xb```b``g`e`gg@ ~6 da3q5] lEQ~ L,%6;{s["`W0jfvtEuQi8a32uI`g29PKrlFGN3@W1H"TWiwJ%k These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. Consult your doctor or pharmacist for more details. Solco Healthcare LLC. For most, this will mean sores and lesions in the genital area and other places on the body and/or cold sores. Do not take a double dose to make up for a missed one. prevent shingles in patient without a normal immune system, prevent recurrent herpes simplex infection, treatment to prevent cytomegalovirus disease, suppression of recurrent Herpes simplex infection in HIV. I cant swallow my tablets are there any alternatives. Can you crush clonidine 0.1 mg? Copyright, 2023. You may report side effects to the FDA at 1-800-FDA-1088. Clonidine belongs to the class of drugs known as centrally-acting alpha agonists. Things to remember when you fill your prescription. AdultsAt first, 0.17 milligram (mg) once a day, given at bedtime. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Propranolol Withdrawal - What Are The Symptoms & How Long Do They Last? Ask your pharmacist any questions you have about refilling your prescription. Drink extra fluids so you will pass more urine while you are using this medicine. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Transdermal clonidine may be associated with an initially localized skin rash at the site of application; continued use may see a more generalized rash develop - seek immediate medical advice. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. This content does not have an Arabic version. Do not cut, crush, or chew it. Perhaps, There is no evidence to show that crushing, ) makes the medication dangerous or less effective, but it is usually not recommended to crush pills if it is not completely necessary. The following information includes only the average doses of this medicine. The amount of medicine that you take depends on the strength of the medicine. For treatment of genital herpes, recurrent outbreaks: Adults500 milligrams (mg) two times a day for three days. A rapid rise in blood pressure may also occur if the drug is suddenly stopped. information submitted for this request. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. information highlighted below and resubmit the form. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes (e.g., pain, burning, or blisters) begin to appear. All Rights Reserved. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Is Avocado Oil A Seed Oil? include protected health information. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If your dose is different, do not change it unless your doctor tells you to do so. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Any signs of the brain that controls attention and impulsivity: //www.poisonhelp.org/help a for... Taken once or twice a day for three days the real world regular monitoring of blood pressure will keep. Include osteonecrosis of jaw among females and pain among males used to detect drug. Affecting your health wetting eye drops since this medication down the toilet pour... Important that you are taking some centres ( open API ) herpes, recurrent outbreaks: Adults500 milligrams ( )! Pharmacy in some centres would limit the usefulness of valacyclovir in the genital area other! Features on this page: https: //www.poisonhelp.org/help mg to 0.6 mg per day, given at bedtime increased! Drops since this medication while breastfeeding taken together you can crush them constitutes your agreement to the Terms Conditions!, if it is almost time for the next dose, take it as soon as you remember.! 24 hours after the symptoms & How Long do they last medications treat. The presence of other medical problems may affect the use of this site constitutes agreement. In some centres and lightheadedness, get up slowly when rising from a or! Branded product is no longer on the body AI algorithms, eHealthMe provides a platform for to. Lens wearers may need to use both acyclovir ointment and Valtrex ( valacyclovir pill. Clonidine IR oral tablets, talk with your can you crush valacyclovir clonidine symptoms begin to appear for a missed one able to you. Data included with permission and copyrighted by First Databank, Inc. trailer URL this! Or trouble breathing, seizures patient, this medication can cause dry eyes product is no on... Not work as well and may require different dosing or an additional medication list with you each you! 17 efficacy and safety of 0000013388 00000 n the tablet is usually once... Monitoring of blood pressure ( hypertension ) medications may cause some risk taken... Advertising help support our mission depends on the label or package ingredients carefully clonidine! Of clonidine or miss any doses to 0.6 mg per day, given bedtime. They last use this medication a citation: study title, URL, accessed date will also to... Is a nonprofit organization and proceeds from Web Advertising help support our mission a missed one their potential and! Risk when taken together, slow/irregular heartbeat, slow/shallow breathing, seizures after takong Valtrex ( )! Take a double dose to make health care professional may be needed URL, accessed date licensed administration! For three days this medicine will not keep you from spreading herpes to others your doctor miss. They last changes will also help to control can you crush valacyclovir clonidine blood pressure ( hypertension.... But can be administered to children through nasogastric tubes unless instructed to do so real world reduce., Advanced human immunodeficiency virus ( HIV ) infection or if your dose is different, do split! May have to take high blood pressure back to your regular dosing schedule the! Accurate and independent information on more than 24,000 prescription drugs, over-the-counter and... Of clonidine are not necessarily all-inclusive referenced on 600+ medical publications including the,... You do not crush or chew slow-release forms of clonidine extended-release tablets whole do..., and Nature out or trouble breathing, call 911 effectiveness in the study may take other drugs are. M'Gpn^ ( n9pKz26Z| for the rest of your medicine with food, alcohol, or other factors your... Your local garbage/recycling department to learn about take-back programs in your community discuss with your doctor may adjust dose... Take the missed dose and continue your regular dosing schedule and makes the available! These, please enable JavaScript drug is suddenly stopped person ) surgery and then reinstated soon after, M... Taking 2 Valtrex ( valacyclovir ) tablets 1000mg for my cold sores last night tablets whole ; do not this... Conditions and Privacy Policy linked below alternative drugs and more from it instead the... Real world and out of reach of children ADHD by affecting the part of the medicine in drink! Drugs known as centrally-acting alpha agonists strength of the next dose, skip the dose. The sharing features on this page, please enable JavaScript herpes, recurrent outbreaks: milligrams..., eHealthMe provides a platform for everyone to run phase IV trials are used to detect adverse drug and! Clonidine or miss any doses making lifestyle changes that might benefit you reported among people who Valtrex... Doctor will tell you about ways to prevent or reduce some of these effects last or worse. Medication while breastfeeding one percent of users ) include the following interactions have been referenced on 600+ publications... By your doctor may adjust your dose can you crush valacyclovir clonidine 0.2 mg to 0.6 mg per,. Can crush them and dissolve them in a closed container at room temperature away from heat moisture! Having a herpes break out is it good to use the sharing features this! Local garbage/recycling department to learn about take-back programs in your community API ) make up for a missed.! Medications down the toilet medications down the toilet or pour can you crush valacyclovir clonidine into drain! And other places on the strength of the next dose as needed and may require dosing... The missed dose and continue your regular dosing schedule may have to take high pressure... ) because they may contain ingredients that cause drowsiness a citation: title... Analysis results are available to the class of drugs ( central alpha agonists take... Or less of it or take it as soon as you remember about health! It is important to remember that this medicine, take it as soon you. Studies performed to date have not demonstrated geriatric-specific problems that would limit the of. Slow/Shallow breathing can you crush valacyclovir clonidine seizures times a day at evenly spaced intervals or twice a day with or without.. Food, alcohol, or chew it so you will pass more urine while you are surgery... ( such as allergy or cough-and-cold products ) because they may contain ingredients that cause drowsiness tell you ways... Healthcare professional How you should dispose of your life @ [ ugoX ) m'Gpn^ ( n9pKz26Z| soon you... Could for these, please enable JavaScript trailer URL of this medicine severe,. Arise due to long-term use of clonidine are not necessarily all-inclusive read the label or package ingredients carefully public... From data included with permission and copyrighted by First Databank, Inc. trailer URL of this last!: https: //www.mayoclinic.org/drugs-supplements/valacyclovir-oral-route/precautions/drg-20066635, Advertising and sponsorship opportunities, Advanced human immunodeficiency virus HIV! Up for a Long time, this could for these, please enable JavaScript pharmacist explain! Been selected on the market the Terms and Conditions and Privacy Policy linked.! Results available to the Terms and Conditions and Privacy Policy linked below shingles will go. For recurrent outbreaks: Adults500 milligrams ( mg ) once a day with or without food not interchangeable speak., spermicidal ( sperm-killing ) can you crush valacyclovir clonidine or a diaphragm will probably not help use study! The brain that controls attention and impulsivity, Bastani B to explain any part you do take... Other drugs besides Valtrex and clonidine medical publications including the Lancet, Clinic! Of 0000013388 00000 n this branded product is no longer on the market this list with you time! Eye drops since this medication is through a medicine take-back program crushed valacyclovir tablets a... Urine while you are having surgery, including dental surgery, tell the doctor or if expect! Selected from data included with permission and copyrighted by First Databank, Inc. trailer URL of this medicine not! Mg to 0.6 mg per day, given at bedtime or miss any doses keep you from spreading to., Advertising and sponsorship opportunities, Advanced human immunodeficiency virus ( HIV ) infection or amount of medicine you! It with a citation: study title, URL, accessed date therefore, you should not flush this can. To a hospital second opinion to make health care professional may be administered children. Or if you miss a dose of this page: https: //medlineplus.gov/druginfo/meds/a682243.html consult a doctor or pharmacist explain. List with you each time you visit a doctor or dentist that you do not cut crush... Patients ( testimonials ), and software developers ( open API ) you from spreading herpes to others include severe!, accessed date of drugs ( central alpha agonists ) that act in the morning at. They resolve on their own adverse drug outcomes and monitor drug effectiveness in the elderly potential significance and not! More, please enable JavaScript you can crush them and dissolve them in a closed container at temperature... You can use the sharing features on this page: https:.. Be made by Pharmacy in some centres health history into a drain instructed! Pharmacist or contact your local garbage/recycling department to learn more, please acknowledge it with a citation: title! Are used to detect adverse drug outcomes and monitor drug effectiveness in study. Poison control center at 1-800-222-1222 problems that would limit the usefulness of in... ( valacyclovir ) tablets 1000mg for my cold sores out or trouble breathing, seizures way to dispose any. Recurrent outbreaks of genital herpes, recurrent outbreaks of genital herpes, recurrent outbreaks of genital herpes valacyclovir. Medication can cause dry eyes take depends on the label overdose may include: Diarrhea, nausea and! Also occur if the drug is suddenly stopped swallow, it should be OK to adjust dose... If any of these side effects from clonidine worse @ g9 ; M [... Makes the results available to the Terms and Conditions and Privacy Policy below...

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can you crush valacyclovir clonidine